The Sacrifice of Isaac is a work of exceptional importance for the study of early Caravaggist naturalism in Naples. Attributed to the enigmatic Master of Resina, the painting was first presented during the landmark 1991-1992 exhibition dedicated to Battistello Caracciolo. Ferdinando Bologna highlighted its outstanding quality and direct references to Caravaggio, such as the angel inspired by the Seven Works of Mercy and the ram derived from the Saint John the Baptist in the Galleria Borghese. With a style that is both archaic and remarkably expressive, the work reveals an early and genuine assimilation of Caravaggio's language. The Master of Resina emerges as a highly original figure of the early 17th century, closely connected to key artists like Carlo Sellitto and Filippo Vitale.